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Actuarial survival rates were estimated using the Kaplan�CMeier method. Differences in survival were studied with the log-rank test. A p value of <0.05 was considered statistically significant. Data from databases of the Hospital Universitari Vall d'Hebron and Hospital Cl��nic were collected prospectively and analyzed <a href="">CT99021 solubility dmso retrospectively. This review was approved by the institutional review boards of both hospitals. Between January 1994 and November 2007, 14 patients (8 women and 6 men) underwent surgery for melanoma liver metastases; the median age at liver surgery was 49.5 years (range 25�C68 years). Median follow-up was 26.6 months (range 0.5�C103.5 months). The primary tumor was cutaneous in 8 patients (57.1%) and ocular in 6 (42.9%). The primary treatment and adjuvant therapies are summarized in Table 1. The majority of patients did not receive systemic therapy after the primary treatment. Only 4 patients (28.6%), all with cutaneous melanoma, received immunotherapy after melanoma treatment (interferon, melanoma cell vaccine, or a combination of both treatments). The characteristics of patients with liver metastases according to the primary site are summarized in Table 1. Synchronous liver metastases were diagnosed in two patients, 2 and 0.7 months after the primary melanoma treatment. Liver resection was performed PLX4032 concentration 1.5 and 1.9 months, respectively, after their diagnoses. The remaining 12 patients developed metachronous metastases during follow-up. The median time between the melanoma treatment and the diagnosis Regorafenib of liver metastasis was 49.1 months (range 6.7�C120.7 months). The median time between the diagnosis of liver metastasis and resection was 2.1 months (range 0�C5.9 months). None of these patients received systemic treatment prior to the liver surgery. In two patients (patients 8 and 13; numbers listed in Tables 2 and 3), the diagnosis of liver metastasis was made during urgent laparotomy, performed because of hemoperitoneum that occurred due to metastasis bleeding. One patient (patient 3) had metastatic axillary lymph nodes diagnosed during preoperative staging prior to the liver surgery. As an exception of the selection criteria, the patient underwent liver resection. Metastatic lymph nodes were resected at the same time as hepatic metastases. In the two patients who underwent urgent laparotomy, complete preoperative staging could not be done. In one of these patients, a suprarenal metastasis was discovered during the liver surgery and resected. The other patient had brain metastases diagnosed during the postoperative course. None of the patients presented with liver cirrhosis or ascites at the time of surgery. Normal liver function was found in all patients, with a prothrombin time of 11�C13 seconds, bilirubin <1.0 mg/dl, and alanine aminotransferase (ALT) level of <200 UI. Intraoperative liver ultrasound was performed in all patients to detect metastases not diagnosed before surgery.</div>
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